anti- BACE1 antibody

Host

Rabbit

Uniprot ID

P56817

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Responsible for the proteolytic processing of the amyloid precursor protein(APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Immunogen

beta-site APP-cleaving enzyme 1

Synonyms

BACE, KIAA1149

Observed MW

70-75 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IP, IHC

Recommended dilution

WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:100-1:400

Gene ID

23621

Research Area

Neuroscience, Metabolism