anti- Autotaxin antibody

Host

Rabbit

Uniprot ID

Q13822

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Hydrolyzes lysophospholipids to produce lysophosphatidic acid(LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Immunogen

ectonucleotide pyrophosphatase/phosphodiesterase 2

Synonyms

ATX, ATX X, Autotaxin, E NPP 2, ENPP2, FLJ26803, LysoPLD, PD IALPHA, PDNP2

Observed MW

100kd

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IP

Recommended dilution

WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200

Gene ID

Research Area

Immunology, Cardiovascular, Metabolism