anti- ATG4B antibody

Host

Rabbit

Uniprot ID

Q9Y4P1

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Cysteine protease required for the cytoplasm to vacuole transport(Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine(PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Immunogen

ATG4 autophagy related 4 homolog B(S. cerevisiae)

Synonyms

APG4B, AUTL1, KIAA0943

Observed MW

44 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IP

Recommended dilution

WB: 1:500-1:2000; IP: 1:500-1:2000 ; IHC: 1:20-1:200

Gene ID

23192

Research Area

Cardiovascular, Metabolism