anti- ARHGEF7 antibody

Host

Rabbit

Uniprot ID

Q14155

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Acts as a RAC1 guanine nucleotide exchange factor(GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions(By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

Immunogen

Rho guanine nucleotide exchange factor(GEF) 7

Synonyms

COOL1, KIAA0142, P85SPR, PAK3BP, PIXB

Observed MW

70 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, IP, WB

Recommended dilution

WB: 1:1000-1:4000; IP: 1:500-1:2000

Gene ID

8874

Research Area

Signal Transduction