anti- ARHGEF4 antibody

Host

Rabbit

Uniprot ID

Q9NR80

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Acts as guanine nucleotide exchange factor(GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Immunogen

Rho guanine nucleotide exchange factor(GEF) 4

Synonyms

KIAA1112

Observed MW

72 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, IHC, WB

Recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

Gene ID

50649

Research Area

Neuroscience, Signal Transduction