anti- APEX1 antibody

Host

Rabbit

Uniprot ID

P27695

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Immunogen

APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms

APE, APE1, APEX, APX, HAP1, REF1

Observed MW

39 kDa

Reactivity

Human

Tested Application

ELISA, WB, IP, IF

Recommended dilution

WB: 1:500 - 1:2000; IF: 1:50 - 1:100; IP: 1:50 - 1:200

Gene ID

328

Research Area

Cardiovascular, Metabolism