SKU:ABCF00384
anti- Angiotensinogen antibody
anti- Angiotensinogen antibody
Host
Mouse
Uniprot ID
P01019
Form
liquid
Purification
Protein A+G purification
Purity
? 95% as determined by SDS-PAGE
Clonality
monoclonal
Clone ID
0F2
Isotype
IgG2b
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Angiotensinogen is a precursor of angiotensin II(Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme(ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Immunogen
angiotensinogen(serpin peptidase inhibitor, clade A, member 8)
Synonyms
AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, FLJ92595, FLJ97926, Serpin A8, SERPINA8
Observed MW
53 kDa
Reactivity
Human
Tested Application
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Gene ID
183
Research Area
Cardiovascular, Metabolism