anti- AMACR/p504S antibody

Host

Rabbit

Uniprot ID

Q9UHK6

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).

Immunogen

alpha-methylacyl-CoA racemase

Synonyms

2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE

Observed MW

42 kDa

Reactivity

Human

Tested Application

ELISA, IHC, WB

Recommended dilution

WB: 1:500-1:5000; IHC: 1:20-1:200

Gene ID

Research Area

Stem Cells, Immunology, Metabolism, Cancer