anti- alpha 1 Antichymotrypsin / AACT antibody

Host

Mouse

Uniprot ID

P01011

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

8F10

Isotype

IgG2b

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Human SerpinA3, also known as Alpha 1-antichymotrypsin(AACT), is a member of the serine protease inhibitor class, and is a plasma alpha globulin glycoprotein which increases in the blood during the inflammatory process. SerpinA3, is also an inhibitor of neutrophil cathepsin G, mast cell chymases and pancreatic chymotrypsin. SerpinA3 is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease. SerpinA3 has also been implicated in the pathology of a number of devastating human diseases including chronic obstructive pulmonary disease(COPD), Parkinson’s disease(PD), Alzheimer’s disease(AD), Stroke, Cystic Fibrosis, Cerebral Haemorrhage and Multiple System Atrophy.

Immunogen

serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 3

Synonyms

A1 Antichymotrypsin, AACT, ACT, Alpha 1 antichymotrypsin, GIG24, GIG25, Serpin A3, SERPINA3

Observed MW

60 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:1000-1:10000; IHC: 1:20-1:300

Gene ID

12

Research Area

Cancer, Immunology, Cardiovascular, Metabolism