anti- ALK,CD246 antibody

Host

Mouse

Uniprot ID

Q9UM73

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

2B10

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

ALK, also named as CD246, is a receptor tyrosine kinase(RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM(Nucleophosmin)-ALK oncogenic fusion protein, resulting from the(2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma(ALCL). The EML4(echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer(NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC(PMID: 17625570).

Immunogen

anaplastic lymphoma receptor tyrosine kinase

Synonyms

ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK

Observed MW

176 kDa

Reactivity

Human

Tested Application

ELISA, IHC, WB

Recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

Gene ID

238

Research Area

Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience