anti- AHR antibody

Host

Rabbit

Uniprot ID

P35869

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes(such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Immunogen

aryl hydrocarbon receptor

Synonyms

Ah receptor, AHR, aryl hydrocarbon receptor, bHLHe76

Observed MW

96 kDa, observed 105 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB, IHC, IP

Recommended dilution

WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200

Gene ID

196

Research Area

Epigenetics, Signal Transduction, Metabolism