SKU:ABCF00216
anti- AGS3 antibody
anti- AGS3 antibody
Host
Rabbit
Uniprot ID
Q86YR5
Form
liquid
Purification
Immunogen affinity purified
Purity
>= 95%
as determined by SDS-PAGEClonality
polyclonal
Clone ID
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory(GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate(GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein(p-CREB).
Immunogen
G-protein signaling modulator 1(AGS3-like, C. elegans)
Synonyms
AGS3, DKFZp727I051, GPSM1
Observed MW
72 kDa
Reactivity
Human, Mouse, Rat
Tested Application
ELISA, IHC, IF, WB
Recommended dilution
WB: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:20-1:200
Gene ID
26086
Research Area
Cell Division and Proliferation, Signal Transduction, Developmental biology