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ABCbiolab

SKU:ABCF00216

anti- AGS3 antibody

anti- AGS3 antibody

Regular price $240.00 USD
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size
Host
Uniprot ID

Host

Rabbit

Uniprot ID

Q86YR5

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

as determined by SDS-PAGE

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory(GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate(GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein(p-CREB).

Immunogen

G-protein signaling modulator 1(AGS3-like, C. elegans)

Synonyms

AGS3, DKFZp727I051, GPSM1

Observed MW

72 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, IHC, IF, WB

Recommended dilution

WB: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:20-1:200

Gene ID

26086

Research Area

Cell Division and Proliferation, Signal Transduction, Developmental biology

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