anti- Aggrecan antibody

Host

Rabbit

Uniprot ID

P16112

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Aggrecan(ACAN), also named as CSPCP, AGC1 and MSK16, belongs to the aggrecan/versican proteoglycan family(also including versican, brevican and neurocan). It is a major component of extracellular matrix of cartilagenous tissues. A major function of aggrecan is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This polyclonal antibody raised against 1-298aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site(PMID: 7852317; 9337874).

Immunogen

aggrecan

Synonyms

ACAN, AGC1, AGCAN, aggrecan, CSPG1, CSPGCP, MSK16, SEDK

Observed MW

250 kDa, observed 70 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:500-1:1000; IHC: 1:20-1:200

Gene ID

Research Area

Stem Cells, Cardiovascular, Metabolism, Developmental biology