anti- Adenylosuccinate lyase antibody

Host

Rabbit

Uniprot ID

P30566

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

ADSL(adenylosuccinate lyase) is also named as AMPS, ASase, ASL and belongs to the lyase 1 family. It is an enzyme involved in 2 pathways of purine nucleotide metabolism and catalyzes cleavage of succinyl groups to yield fumarate(PMID:18524658). Defects in ADSL are the cause of adenylosuccinase deficiency(ADSL deficiency). In humans, mutations in ADSL lead to an inborn error of metabolism originally characterized by developmental delay, often with autistic features(PMID:20884265)..The ADSL enzymatic activity is reduced in lymphocytes and red blood cells of the patient with severe psychomotor retardation(PMID:9545543). It has 2 isoforms produced by alternative splicing.

Immunogen

adenylosuccinate lyase

Synonyms

Adenylosuccinase, adenylosuccinate lyase, ADSL, AMPS, ASASE, ASL

Observed MW

55 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IF, FC

Recommended dilution

WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100

Gene ID

158

Research Area

Metabolism