ANO3 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins| that are also known as anoctamins. While little is known about the function of this gene| mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with| and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human ANO3

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

107910

synonyms

ANO3