Alpha-SMA Polyclonal Antibody

Ab type

Primary antibody

Background

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. Actin alpha cardiac muscle 1/Actin alpha skeletal muscle/Actin aortic smooth muscle/Actin gamma-enteric smooth muscle encoded by ACTC1 belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human α-SMA.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

42019

synonyms

ACTC1; ACTC; Actin, alpha cardiac muscle 1; Alpha-cardiac actin; ACTA1; ACTA; Actin, alpha skeletal muscle; Alpha-actin-1; ACTA2; ACTSA; ACTVS; GIG46;