ALOX12 Antibody

Size

100ug

Clone Number

Aliases

12 LOX antibody; 12(S) lipoxygenase antibody; 12-lipoxygenase antibody; 12LO antibody; 12S LOX antibody; 12S-lipoxygenase antibody; 12S-LOX antibody; 12S-type antibody; Alox12 antibody; Arachidonate 12 lipoxygenase antibody; Arachidonate 12 lipoxygenase, 12S type antibody; Arachidonate 12-lipoxygenase antibody; Arachidonate 12-oxidoreductase antibody; Lipoxin synthase 12-LO antibody; LOG12 antibody; LOX12_HUMAN antibody; P-12LO antibody; Platelet 12-LOX antibody; Platelet type lipoxygenase 12 antibody; platelet-type 12-lipoxygenase antibody; Platelet-type lipoxygenase 12 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P18054

Immunogen

Recombinant Human Arachidonate 12-lipoxygenase, 12S-type protein (508-658AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200

Background

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ALOX12

Research Areas

Cancer; Cardiovascular; Metabolism; Signal transduction