AHRR Antibody

Size

100ug

Clone Number

Aliases

AHH antibody; AhR repressor antibody; AhRR antibody; AHRR_HUMAN antibody; aryl hydrocarbon hydroxylase regulator antibody; aryl hydrocarbon receptor regulator antibody; Aryl hydrocarbon receptor repressor antibody; Arylhydrocarbon receptor repressor antibody; bHLHe77 antibody; Class E basic helix-loop-helix protein 77 antibody; Dioxin receptor repressor antibody; KIAA1234 antibody; MGC167813 antibody; MGC176630 antibody; OTTHUMP00000221488 antibody; OTTHUMP00000221489 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

A9YTQ3

Immunogen

Recombinant Human Aryl hydrocarbon receptor repressor protein (255-506AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

AHRR

Research Areas

Epigenetics and Nuclear Signaling