AHR Antibody

Size

100ug

Clone Number

Aliases

Ah receptor antibody; AhR antibody; AHR_HUMAN antibody; Aromatic hydrocarbon receptor antibody; Aryl hydrocarbon receptor antibody; Aryl hydrocarbon receptor precursor antibody; bHLHe76 antibody; Class E basic helix loop helix protein 76 antibody; Class E basic helix-loop-helix protein 76 antibody; HGNC:348 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P35869

Immunogen

Recombinant Human Aryl hydrocarbon receptor protein (126-353AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

AHR

Research Areas

Epigenetics and Nuclear Signaling