AHCYL1 Antibody

Size

100ul

Clone Number

Aliases

AA409031 antibody; AdoHcyase 2 antibody; Ahcy-rs3 antibody; AHCYL1 antibody; DC expressed AHCY like molecule antibody; DC-expressed AHCY-like molecule antibody; DCAL antibody; Dendritic cell expressed AHCY like protein antibody; Inositol 1,4,5-trisphosphate receptor-binding protein antibody; IP3R binding protein released with inositol 1,4,5-trisphosphate antibody; IRBIT antibody; PRO0233 antibody; Putative adenosylhomocysteinase 2 antibody; S adenosyl L homocysteine hydrolase 2 antibody; S adenosylhomocysteine hydrolase like 1 antibody; S-adenosyl-L-homocysteine hydrolase 2 antibody; S-adenosylhomocysteine hydrolase-like protein 1 antibody; SAHH2_HUMAN antibody; XPVKONA antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43865

Immunogen

Recombinant Human S-adenosylhomocysteine hydrolase-like protein 1 protein (31-260AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3- and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous \\\'pseudoligand\\\' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3- secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression .

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

AHCYL1

Research Areas

Metabolism; Signal transduction