ACTN1 Polyclonal Antibody

Ab type

Primary antibody

Background

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins| including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells| the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions| where it is involved in binding actin to the membrane. In contrast| skeletal| cardiac| and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies| where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle| cytoskeletal| alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from part region of human protein

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

Alpha-actinin-1 ;Alpha-actinin cytoskeletal isoform;F-actin cross-linking protein;Non-muscle alpha-actinin-1