AChR Alpha3 Polyclonal Antibody

Ab type

Primary antibody

Background

CHRNA3 encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. CHRNA3 encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein (cholinergic receptor nicotinic alpha 3 subunit) is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human AChRalpha3. AA range:90-139

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

57310

synonyms

CHRNA3; NACHRA3; Neuronal acetylcholine receptor subunit alpha-3