8ODP Polyclonal Antibody

Ab type

Primary antibody

Background

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates| such as 8-oxo-dGTP| 8-oxo-dATP| 2-hydroxy-dATP| and 2-hydroxy rATP| to monophosphates| thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm| with some in the mitochondria| suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants| some of which encode distinct isoforms| have been identified. Additional variants have been observed| but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional| longer is

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human protein . at AA range: 1-80

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

7; 8-dihydro-8-oxoguanine triphosphatase ;EC 3.6.1.55;2-hydroxy-dATP diphosphatase;EC 3.6.1.56;8-oxo-dGTPase;Nucleoside diphosphate-linked moiety X motif 1;Nudix motif 1