14-3-3 sigma(Phospho Ser186) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners| usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17| regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.|p53-regulated inhibitor of G2/M progression.|Belongs to the 14-3-3 family.|subcellular location:May be secreted by a non-classical secretory pathway.|subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7| EIF4A1| ARHGAP1| VPS26A| VPS29| VPS35 and SFN.|tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.|

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human 14-3-3σ (Phospho Ser186)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

27280

synonyms

Stratifin; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin