11 Beta-HSD1 Polyclonal Antibody

Ab type

Primary antibody

Background

Hydroxysteroid 11-beta dehydrogenase 1 encoded by HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in HSD11B1 has been associated with obesity and insulin resistance in children. Mutations in HSD11B1 and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human HSD11B1. AA range:1-50

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

32401

synonyms

HSD11B1; HSD11; HSD11L; Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1