{"product_id":"zap-70-phospho-tyr315-polyclonal-antibody-abcb07308","title":"ZAP-70(Phospho Tyr315) Polyclonal Antibody","description":"\u003ch4\u003eAb type\u003c\/h4\u003e\u003cp\u003ePrimary antibody\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eThis gene encodes an enzyme belonging to the protein tyrosine kinase family| and it plays a role in T-cell development and lymphocyte activation. This enzyme| which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation| functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases| Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect| a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. \u003c\/p\u003e\u003ch4\u003eReactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eHost\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eThe antiserum was produced against synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr315. AA range:281-330\u003c\/p\u003e\u003ch4\u003eStorage Stability\u003c\/h4\u003e\u003cp\u003e-20°C for 1 year\u003c\/p\u003e\u003ch4\u003eConcentration\u003c\/h4\u003e\u003cp\u003e1 mg\/ml\u003c\/p\u003e\u003ch4\u003eMolecularWeight_Da\u003c\/h4\u003e\u003cp\u003e69872\u003c\/p\u003e\u003ch4\u003esynonyms\u003c\/h4\u003e\u003cp\u003eTyrosine-protein kinase ZAP-70; ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42404532158698,"sku":"ABCB07308","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_56ab27d2-4649-4906-aced-40a484f369fb.png?v=1645223264","url":"https:\/\/danabiosci.com\/products\/zap-70-phospho-tyr315-polyclonal-antibody-abcb07308","provider":"Dana Bioscience","version":"1.0","type":"link"}