{"product_id":"yp-ab-16540-100ul","title":"p21 (Acetyl Lys154) rabbit pAb","description":"\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eGene Name:\u003c\/b\u003e CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eImmunogen:\u003c\/b\u003e Synthesized peptide derived from human p21 (Acetyl Lys154)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSpecificity:\u003c\/b\u003e This antibody detects endogenous levels of Human,Mouse,Rat p21 (Acetyl Lys154)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eComposition:\u003c\/b\u003e Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e Polyclonal, Rabbit,IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eDilution ratio:\u003c\/b\u003e WB 1:1000-2000 ELISA 1:5000-20000\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurification process:\u003c\/b\u003e The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eConcentration:\u003c\/b\u003e 1 mg\/ml\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e -20°C\/1 year\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eOther Names:\u003c\/b\u003e Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eBackground:\u003c\/b\u003e function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.,\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFunction:\u003c\/b\u003e regulation of cyclin-dependent protein kinase activity, G1\/S transition of mitotic cell cycle, G2\/M transition of mitotic cell cycle, mitotic cell cycle, regulation of cell growth, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, negative regulation of protein kinase activity, induction of apoptosis, response to DNA damage stimulus, cell cycle, cell cycle arrest, positive regulation of cell proliferation,negative regulation of cell proliferation, regulation of cell size, induction of apoptosis by intracellular signals, response to radiation, response to UV, response to light stimulus, response to abiotic stimulus, response to toxin, response to endogenous stimulus, response to hormone stimulus, response to extracellular stimulus, response to organic substance, response to inorganic substance, response to organi\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human;Mouse;Rat\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eRange:\u003c\/b\u003e WB; ELISA\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eProtein:\u003c\/b\u003e p21 (Acetyl Lys154)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eDA:\u003c\/b\u003e 21kD\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Upingbio","offers":[{"title":"100UL","offer_id":50691422585112,"sku":"YP-Ab-16540-100UL","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/images_efd9c35f-105b-4b59-9f24-e961a1e661ee.png?v=1758629459","url":"https:\/\/danabiosci.com\/products\/yp-ab-16540-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}