{"product_id":"yp-ab-04267-100ul","title":"VPS72 Polyclonal Antibody","description":"\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eGene Name:\u003c\/b\u003e VPS72\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eImmunogen:\u003c\/b\u003e The antiserum was produced against synthesized peptide derived from human VPS72. AA range:131-180\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSpecificity:\u003c\/b\u003e VPS72 Polyclonal Antibody detects endogenous levels of VPS72 protein.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eComposition:\u003c\/b\u003e Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e Polyclonal, Rabbit,IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eDilution ratio:\u003c\/b\u003e Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurification process:\u003c\/b\u003e The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eConcentration:\u003c\/b\u003e 1 mg\/ml\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e -20°C\/1 year\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eOther Names:\u003c\/b\u003e VPS72; TCFL1; YL1; Vacuolar protein sorting-associated protein 72 homolog; Protein YL-1; Transcription factor-like 1\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eBackground:\u003c\/b\u003e The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP\/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP\/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012],\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFunction:\u003c\/b\u003e function:Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the VPS72\/YL1 family.,subunit:Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit HTATIP\/TIP60 and the subunits EP400, TRRAP\/PAF400, BRD8\/SMAP, EPC1, DMAP1\/DNMAP1, RUVBL1\/TIP49, RUVBL2, ING3, actin, ACTL6A\/BAF53A, MORF4L1\/MRG15, MORF4L2\/MRGX, MRGBP, YEATS4\/GAS41 and VPS72\/YL1. Component of a NuA4-related complex which contains EP400, TRRAP\/PAF400, SRCAP, BRD8\/SMAP, EPC1, DMAP1\/DNMAP1, RUVBL1\/TIP49, RUVBL2, actin, ACTL6A\/BAF53A, VPS72 and YEATS4\/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ\/H2AZ.,\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human;Mouse\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eRange:\u003c\/b\u003e WB;IHC;IF;ELISA\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eProtein:\u003c\/b\u003e Vacuolar protein sorting-associated protein 72 homolog\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eDA:\u003c\/b\u003e 41kD\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Upingbio","offers":[{"title":"100UL","offer_id":50689997832472,"sku":"YP-Ab-04267-100UL","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/images_6fedd8fe-0159-467c-8465-8e68fb8d5f73.png?v=1758595791","url":"https:\/\/danabiosci.com\/products\/yp-ab-04267-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}