{"product_id":"yp-ab-03400-53ul","title":"HAS1 Monoclonal Antibody","description":"\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eReaction species:\u003c\/b\u003e Human\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eGene Name:\u003c\/b\u003e HAS1\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eProtein name:\u003c\/b\u003e Hyaluronan synthase 1\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eImmunogen:\u003c\/b\u003e Purified recombinant fragment of human HAS1 expressed in E. Coli.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSpecificity:\u003c\/b\u003e HAS1 Monoclonal Antibody detects endogenous levels of HAS1 protein.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eComposition:\u003c\/b\u003e Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e Monoclonal, Mouse\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eDilution ratio:\u003c\/b\u003e Western Blot: 1\/500 - 1\/2000. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurification process:\u003c\/b\u003e Affinity purification\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e -20°C\/1 year\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eBackground:\u003c\/b\u003e Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheuma\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFunction:\u003c\/b\u003e catalytic activity:UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-\u0026gt;4)-beta-D-glucuronosyl-(1-\u0026gt;3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1-\u0026gt;3)-N-acetyl-beta-D-glucosaminyl-(1-\u0026gt;4)-beta-D-glucuronosyl-(1-\u0026gt;3)-(nascent hyaluronan).,catalytic activity:UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-\u0026gt;3)-N-acetyl-beta-D-glucosaminyl-(1-\u0026gt;4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1-\u0026gt;4)-beta-D-glucuronosyl-(1-\u0026gt;3)-N-acetyl-beta-D-glucosaminyl-(1-\u0026gt;4)-(nascent hyaluronan).,cofactor:Magnesium.,function:Plays a role in hyaluronan\/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.,online information:GlycoGene database,pathway:Glycan biosynthesis; hyaluronan biosynthesis.,similarity:Belongs to the nodC\/HAS family.,tissue specificity:Highly expressed in ovary followed by spleen, thymus,\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Upingbio","offers":[{"title":"53UL","offer_id":50688882311448,"sku":"YP-Ab-03400-53UL","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/images_4af48415-adf9-491e-aaa9-842a44aa1adf.png?v=1758556857","url":"https:\/\/danabiosci.com\/products\/yp-ab-03400-53ul","provider":"Dana Bioscience","version":"1.0","type":"link"}