• MACC1 Polyclonal Antibody
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Upingbio

YP-Ab-02232-100UL

MACC1 Polyclonal Antibody

MACC1 Polyclonal Antibody

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  • Gene Name: MACC1
  • Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460
  • Specificity: MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
  • Background: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],
  • Function: function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors.,tissue specificity:Preferentially expressed in metastasizing tumors.,
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: Metastasis-associated in colon cancer protein 1
  • DA: 97kD
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