{"product_id":"v9223-20ug","title":"Transcription factor Spi-C \/ SPIC","description":"\u003cp\u003eThe Ets transcription factor family is comprised of DNA-binding proteins that influence lymphoid development and activity and bind the consensus DNA site GGA(A\/T) through a unique winged helix-turn-helix motif known as the Ets domain. Spi-B and Spi-C (also known as SPIC) are closely related Ets family members which share a conserved divergent sequence within the Ets domain that enables their binding to non-canonical AGAA sites. Spi-C is a 248 amino acid protein that localizes to the nucleus and, like other Ets family members, binds DNA as a monomer and plays a role in transcriptional regulation. Addi- tionally, Spi-C is thought to control the development of red pulp macrophages, thereby contributing to iron homeostasis and red blood cell recycling. Human Spi-C shares 65% amino acid identity with its mouse counterpart, suggesting a conserved role between species.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49429602828568,"sku":"V9223-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_1c61ac81-8611-4db9-bb57-338711677b21.jpg?v=1733304258","url":"https:\/\/danabiosci.com\/products\/v9223-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}