{"product_id":"v8948-100ug","title":"PU.1 Antibody \/ SPI1","description":"\u003cp\u003ePU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Mouse","offer_id":49429768339736,"sku":"V8948-100UG","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_c6c0b8e9-ec85-4b90-a0da-bcdb55f7ff30.jpg?v=1733306607","url":"https:\/\/danabiosci.com\/products\/v8948-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}