{"product_id":"v8353-20ug","title":"CD137 Antibody \/ 4-1BB \/ TNFRSF9","description":"\u003cp\u003eCD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Rat","offer_id":49430006399256,"sku":"V8353-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/v8353-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}