{"product_id":"v8347-20ug","title":"PDCD1 Antibody \/ PD-1 \/ PD1","description":"PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1 mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. \u003cstrong\u003eThe RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells).\u003c\/strong\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Rat","offer_id":49430008594712,"sku":"V8347-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_bb19fa76-c994-4541-a4ad-4423886c4746.jpg?v=1733310566","url":"https:\/\/danabiosci.com\/products\/v8347-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}