{"product_id":"v8338-20ug","title":"HPV-16 E1\/E4 Antibody","description":"\u003cp\u003eThe human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1\/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1\/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1\/cyclin B1 complexes. HPV16E1\/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1\/E4 is able to prevent mitotic entry. HPV16E1\/E4 also associates with keratin intermediate filaments and causes the network to collapse.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49430010495256,"sku":"V8338-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b75e41c6-7be2-44ad-9906-a76f0a3a5d80.jpg?v=1733310602","url":"https:\/\/danabiosci.com\/products\/v8338-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}