{"product_id":"v8291-100ug","title":"Cig2 Antibody","description":"\u003cp\u003eCig2 is a cyclin that functions as the catalytic subunit of cyclin-dependent kinases (Cdks) in the fission yeast Schizosaccharomyces pombe. It is a B-type, S phase cyclin that is required for both the G1\/S and G2\/M cell cycle transitions and is expressed in a sharp spike that peaks during the G1\/S period. Cig2 binds to Cdc2 (Cdk), and the resulting Cdc2\/Cig2 complex controls the G1\/S transition of the cell cycle. Disruption of Cig2 delays the onset of mitosis. The expression of the Cig2 gene is dependent on Mlu1-binding factor (MBF), and the protein is destroyed during anaphase by the APC\/cyclosome (APC\/C) and Skp1\/Cullin-1\/F-box (SCF), thereby ensuring the spike expression pattern of Cig2. SCF regulates Cig2 levels in a dual manner, transcriptionally and post-translationally, while APC\/C only destroys the protein.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Mouse","offer_id":49430037758232,"sku":"V8291-100UG","price":539.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/v8291-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}