{"product_id":"v8029-20ug","title":"Calcineurin B Antibody \/ PPP3R1","description":"\u003cp\u003eCalcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49430162964760,"sku":"V8029-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/v8029-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}