{"product_id":"v7700-100ug","title":"CTLA-4 Antibody \/ CD152","description":"\u003cstrong\u003eThis CTLA4 antibody is specific to the soluble form of the protein.\u003c\/strong\u003e CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Mouse","offer_id":49431171399960,"sku":"V7700-100UG","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b47d182a-1e72-4bc7-9b15-039cf5cd80fe.jpg?v=1733339625","url":"https:\/\/danabiosci.com\/products\/v7700-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}