{"product_id":"v7410ihc-7ml","title":"ALK Antibody \/ Anaplastic Lymphoma Kinase","description":"\u003cp\u003eThe wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene, NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"7 ml \/ Rabbit","offer_id":49431265640728,"sku":"V7410IHC-7ML","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_50fbb733-1ca9-4340-8a4f-86006974f4b2.jpg?v=1733342296","url":"https:\/\/danabiosci.com\/products\/v7410ihc-7ml","provider":"Dana Bioscience","version":"1.0","type":"link"}