{"product_id":"v7163-20ug","title":"TNF alpha Antibody","description":"\u003cp\u003eTumor Necrosis Factor Alpha (TNF alpha) is a cytokine that binds to TNFRSF1A\/TNFR1 and TNFRSF1B\/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO\/SMAC mimetic in the RT4v6 bladder cancer cell line. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49431346479384,"sku":"V7163-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_4c1cdb42-bcf3-424a-b357-537885336f2c.jpg?v=1733344417","url":"https:\/\/danabiosci.com\/products\/v7163-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}