{"product_id":"v4906-20ug","title":"IL-1RA Antibody \/ Interleukin-1 Receptor Antagonist \/ IL1RN","description":"\u003cp\u003eTwo forms of interleukin-1, designated IL-1a and IL-1beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1a and IL-1beta bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation acting as an activator of T and B lymphocytes and natural killer (NK) cells. IL-1 receptor antagonist (IL-1ra) is a cytokine that inhibits IL-1a and IL-1beta binding to interleukin receptors. By neutralizing the activity of IL-1, IL-1ra contributes to the inhibition of the immune and inflammatory responses and has been targeted as a drug for the treatment of severely active rheumatoid arthritis. There are four isoforms of IL-1ra that are produced as a result of alternative splicing events.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49431667114264,"sku":"V4906-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_6d85790b-6364-460b-88b7-1ff0ac8e73b9.jpg?v=1733351746","url":"https:\/\/danabiosci.com\/products\/v4906-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}