{"product_id":"v4766-20ug","title":"COX2 Antibody \/ PTGS2","description":"\u003cp\u003eProstaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49473861353752,"sku":"V4766-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_36242c07-0b92-4e5c-b632-c8d854d793d4.jpg?v=1734420048","url":"https:\/\/danabiosci.com\/products\/v4766-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}