{"product_id":"v4199-100ug","title":"IL-18 Antibody","description":"\u003cp\u003eFour structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1Alpha, IL-1beta and IL-1gamma\/IL-18 and a specific receptor antagonist, IL-1RAlpha. IL-1Alpha and IL-1beta play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1gamma) has been shown to augment the secretion of IFN-gamma from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1Alpha and IL-1beta respectively over the 12 beta-strands of the beta-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1beta pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-gamma-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Mouse","offer_id":49474210365720,"sku":"V4199-100UG","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_071229b9-3dd5-4701-8246-a6d1f3f29b02.jpg?v=1734425750","url":"https:\/\/danabiosci.com\/products\/v4199-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}