{"product_id":"v3552saf-100ug","title":"CFTR Antibody \/ Cystic Fibrosis Transmembrane Regulator","description":"\u003cp\u003eCFTR functions as an ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl+\/-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.[5] This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation. CFTR is found in the epithelial cells of many organs including the lung, liver, pancreas, digestive tract, and the reproductive tract. [Wiki]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Mouse","offer_id":49474479489304,"sku":"V3552SAF-100UG","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_3ee4abf1-c5b0-48aa-8a51-8660c4ee0458.jpg?v=1734432281","url":"https:\/\/danabiosci.com\/products\/v3552saf-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}