{"product_id":"v3180-100ug","title":"CD74 \/ CLIP Antibody","description":"\u003cp\u003eRecognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74\/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74\/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha\/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74\/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74\/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Mouse","offer_id":49474570846488,"sku":"V3180-100UG","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_a7652273-d1f3-40bf-8611-2fccc98929d9.jpg?v=1734435251","url":"https:\/\/danabiosci.com\/products\/v3180-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}