{"product_id":"v3050-20ug","title":"GITR Antibody \/ TNFRSF18","description":"\u003cp\u003eGITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Rat","offer_id":49474596503832,"sku":"V3050-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_4a5c89ea-4579-4476-bd89-b083fbd55230.jpg?v=1734436573","url":"https:\/\/danabiosci.com\/products\/v3050-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}