{"product_id":"v3029-20ug","title":"CD63 Antibody \/ LAMP-3","description":"\u003cp\u003eThis mAb recognizes protein of 26kDa-60kDa, which is identified as CD63\/LAMP-3. Its epitope is different from that of mAb LAMP3\/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63\/LAMP-3 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. It is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63\/LAMP-3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49474600763672,"sku":"V3029-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_3901b8a7-0b30-4d7f-b932-bc1533e0539f.jpg?v=1734436751","url":"https:\/\/danabiosci.com\/products\/v3029-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}