{"product_id":"v2947-20ug","title":"Cyclin B1 Antibody \/ CCNB1","description":"\u003cp\u003eIt recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2\/M boundary. This mitotic kinase complex remains active until the metaphase\/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49474616983832,"sku":"V2947-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_60f74c26-4a32-43ab-a9af-cb635aa869f3.jpg?v=1734437356","url":"https:\/\/danabiosci.com\/products\/v2947-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}