{"product_id":"v2604-20ug","title":"ICAM1 Antibody \/ CD54","description":"\u003cp\u003eRecognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1) (Workshop IV). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a\/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b\/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. W-CAM-1 mAb blocks aggregation of cell lines mediated by the ICAM-1 and blocks homotypic binding of purified populations of activated T- and B-lymphocytes and also aggregation of mixed T- and B-cell blasts. It inhibits T-cell adhesion to normal human endothelial cells. Activation induced by cell-cell contact (mixed lymphocyte reaction, T-cell mediated B-cell activation) is significantly inhibited. This mAb blocks elements of both effector arms of immune system (cytotoxic cell function and Ig production).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49474699002136,"sku":"V2604-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b4780e84-7b98-4509-a407-bd8e7ba59847.jpg?v=1734440955","url":"https:\/\/danabiosci.com\/products\/v2604-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}