{"product_id":"v2587-20ug","title":"HLA-DRB1 Antibody (MHC II)","description":"This mAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The SPM289 antibody recognizes a different epitope than the \u003ca href=\"..\/tds\/hla-drb1-antibody-l243-v2591\"\u003eL243 monoclonal antibody\u003c\/a\u003e, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes\/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3\/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":49474703556888,"sku":"V2587-20UG","price":249.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_0fa3bfe5-781e-47d8-9feb-4103f0b0aac5.jpg?v=1734441171","url":"https:\/\/danabiosci.com\/products\/v2587-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}